期刊
CURRENT OPINION IN IMMUNOLOGY
卷 24, 期 5, 页码 522-529出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.08.001
关键词
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类别
资金
- Crohn's and Colitis Foundation of America
- NIH [DK043351, DK083756, DK086502]
Genetic studies of inflammatory bowel disease (IBD) have identified multiple risk loci that contain genes involved in autophagy. Although autophagy was traditionally considered to be a homeostatic response to ensure the recycling of cellular materials, it has now been additionally established to have roles in immunity and inflammation. In this review, we highlight how genetics have begun to identify a broader role for autophagy as a key pathway in Crohn's disease (CD). We review recent studies that have implicated autophagy in the regulation of mucosal homeostasis, including roles in intracellular defense, vesicular trafficking, and inflammatory signaling. Finally, we discuss studies that have begun to demonstrate how CD risk polymorphisms cause defects in autophagy and promote a breakdown of intestinal homeostasis.
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