期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 4, 页码 448-455出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.06.001
关键词
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类别
资金
- Japan Initiative for Global Research Network on Infectious Diseases
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Naito Foundation
- Waksman Foundation of Japan Inc.
- Yakult Bio-Science Foundation
- [23000012]
- [20229006]
- [23790471]
- [23790472]
- [22790403]
- [23390102]
- [23659220]
- [18073003]
- Grants-in-Aid for Scientific Research [23390102, 23790471] Funding Source: KAKEN
The intestinal mucosa is equipped with multiple innate immune defense systems that sense bacterial infection, transmit alarm signals to the immune system, defeat intruding bacteria, and renew damaged and aging epithelial cells. Nevertheless, mucosal bacterial pathogens have versatile pathogenic mechanisms that modulate the host inflammatory and immune responses, manipulate host cell death and survival signal pathways, and renovate the injured epithelium. These properties enable pathogens to adapt to the intestinal mucosal environment, exploit cellular and immune functions, and facilitate infection. Here we review current topics on host defense mechanisms against bacterial infection and the countermeasures that Shigella use to evade the innate immune system.
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