期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 1, 页码 46-56出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.10.021
关键词
-
类别
资金
- Medical Research Council [MC_U117512710, MC_U117565642] Funding Source: Medline
- Medical Research Council [MC_U117512710, MC_U117565642] Funding Source: researchfish
- MRC [MC_U117512710, MC_U117565642] Funding Source: UKRI
The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type land Type II interferons and several, including TRIM5 alpha and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据