期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 1, 页码 57-64出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.11.003
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资金
- National Institutes of Health [R01 AI069120, R01 AI078389, PN2EY018228]
Type I interferons (IFNs) are cytokines of the innate immune system that induce antiviral protein expression in response to viral infection. Various proteins and pathways have been shown to recognize nucleic acid ligands especially from RNA viruses. Here, we will review recent developments including transcription of DNA virus genomes into RNA ligands, and the recognition of viruses by TLR2 for interferon induction. The induced IFNs activate many interferon stimulated genes (ISGs) that have direct antiviral effects. Recent studies have identified IFITM proteins as the first ISG to inhibit viral entry processes and revealed mechanistic understanding of known antiviral ISGs such as ISG15 and Viperin.
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