期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 3, 页码 330-336出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.03.004
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资金
- INSERM
- Sanofi-Pasteur
Despite being unable to mount a bona fide recall antibody (Ab) response to secondary immunization, T cell-independent antigens (TI Ag) such as pneumococcal capsular polysaccharides (PS) can generate protective humoral immunity in adults. The concept of TI B cell memory after being iconoclastic for decades has now received experimental support from several laboratories. TI B cell memory comprises two components: i) memory B lymphocytes that differ phenotypically and functionally from their T cell-dependent counterparts, ii) memory bone marrow plasma cells that play a crucial role in the immune protection conferred by TI polysaccharidic vaccines. B-1b cells constitute the major source of both TI memory lymphocytes and plasma cells. This conceptual shift should lead to rehabilitate the TI arm of the immune system for vaccination purposes.
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