期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 5, 页码 613-619出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.07.006
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资金
- National Institutes of Health [AR054389]
The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL-17A and IL-17F and their cognate receptors. To dale, far less is known about the rest of the family. This review discusses recent advances in the field, with an emphasis on IL-17A biology.
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