期刊
CURRENT OPINION IN IMMUNOLOGY
卷 22, 期 4, 页码 514-520出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.04.009
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资金
- Research into Ageing and the Human Frontiers Science Program
A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the Multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting and activating cells, recent work shows that some subpopulations of B cells can have suppressive functions. The diversity of the B cell population as a whole decreases with age, and is associated with ill health. Whether decreased diversity is a feature of all B cells or a reflection of altered subpopulations is not clear, since different subsets of B cells have different functions and their repertoires are shaped by different selection pressures.
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