期刊
CURRENT OPINION IN IMMUNOLOGY
卷 22, 期 5, 页码 634-642出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.08.017
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资金
- National Institutes of Health
- Juvenile Diabetes Research Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL106018, R01HL056819] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK069275] Funding Source: NIH RePORTER
Stress induced activation or denudation of the endothelium elicits arrest and activation of platelets with attendant triggering of coagulation, culminating in a physical barrier to limit blood loss Recently coagulation-activated osteopontin chemerin and protease-activated receptor signaling, as well as platelet-derived molecules including platelet factor 4 serotonin P-selectin, and CD154 (CD40L) have been revealed as new links between hemostasis and adaptive immunity The initiation of hemostasis establishes a local state of inflammation that serves as an adjuvant system for antigen presentation consequently influencing the onset and functional characteristics of an evolving adaptive immune response In this context the hemostatic system and its associated signaling pathways warrant further study as novel therapeutic targets that may enhance abrogate or otherwise selectively direct the adaptive immune response
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