期刊
CURRENT OPINION IN IMMUNOLOGY
卷 21, 期 1, 页码 63-67出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.01.011
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- NHLBI NIH HHS [R01 HL091531, R01 HL091531-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK065029-05, R01 DK065029] Funding Source: Medline
Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron availability to microbial invaders. Some microbes have evolved effective countermeasures that blunt the effect of iron restriction. Recent epidemiologic studies have highlighted the potentiating effect of iron on microbial infections. Laboratory studies have focused on specific immune mechanisms that mediate iron withholding from microbes constitutively and in response to infections. Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections.
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