期刊
CURRENT OPINION IN IMMUNOLOGY
卷 21, 期 3, 页码 281-285出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.05.007
关键词
-
类别
资金
- JDRF
- NIAID
- NIDDK
- Swiss National Science Foundation
- Roche Research Foundation
- Novartis Foundation
- CibaGeigy Jubilee Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR014884] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007090, R37AI046643] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK063720] Funding Source: NIH RePORTER
Regulatory T (Treg) cells play an essential role in maintaining immunological tolerance. The discovery of FoxP3 as a key Treg transcription factor combined with recent advances in the development of functional reporter mice has enabled new insights into Treg biology and revealed unexpected features of this lineage. In this review, we address the stability of this population, focusing on studies that suggest that Tregs can downregulate FoxP3, lose regulatory activity and, under some conditions, become memory T cells capable of recognizing self-antigens and expressing effector cell activities including the production of IL-17 and IFN-gamma. The presence of these 'exTregs' in multiple inflammatory settings suggests a potential role for these cells in a variety of disease settings ranging from autoimmunity to cancer and infectious disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据