期刊
CURRENT OPINION IN IMMUNOLOGY
卷 20, 期 2, 页码 158-161出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2008.03.015
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资金
- NHLBI NIH HHS [T32 HL007971, T32-HL07971] Funding Source: Medline
- NIAID NIH HHS [R01 AI073939, T32 AI055428, R01 AI054488, R01-AI0545488, R01 AI073939-01, R01 AI054488-04] Funding Source: Medline
- PHS HHS [R01-073939] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007971] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI055428, R01AI054488, R01AI073939] Funding Source: NIH RePORTER
BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.
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