期刊
CURRENT OPINION IN IMMUNOLOGY
卷 20, 期 2, 页码 149-157出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2008.03.014
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI057486, R01AI064930] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI064930, R01 AI064930-03, R21 AI057486, R21 AI057486-01] Funding Source: Medline
Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.
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