期刊
CURRENT OPINION IN HEMATOLOGY
卷 18, 期 3, 页码 191-196出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0b013e328345a3d1
关键词
angiopoietin-1; angiopoietin-2; endothelial activation; endothelial permeability; sepsis
类别
资金
- Canada Research Chair in Infectious Diseases and Inflammation
- Canadian Institutes of Health Research (CIHR)
- Ontario Thoracic Society and the Physicians' Services Incorporated Foundation
Purpose of review Over the last few years, there have been major advances in our understanding of the role of the microvascular endothelium in the pathogenesis of severe, systemic infections. Recent findings Endothelial activation and dysfunction contribute directly to the morbidity and mortality of sepsis and other, severe systemic infections. The end-result of diffuse endothelial activation and dysfunction may be the loss of microvascular barrier integrity, leading to tissue edema, shock and multiple organ failure. Endothelial activation also leads to an increase in angiopoietin-2, which is known to destabilize barrier function and promote inflammation. Summary The ratio of the secreted endothelial growth factors, angiopoietin-2 and angiopoietin-1 appears to be a useful prognostic tool during severe infections. Finally, agents that enhance endothelial barrier integrity may prove useful as therapies for sepsis.
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