期刊
CURRENT OPINION IN HEMATOLOGY
卷 17, 期 4, 页码 313-318出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0b013e328339f295
关键词
blood flow; hematopoietic stem cell; hemogenic endothelium; lineage tracing; placenta
类别
资金
- National Institutes of Health [NIH HL097766-01]
- California Institute for Regenerative Medicine [CIRM RN1-00557-1, RS1-00420-1, CIRM TG2-01169]
- Ruth Kirschstein National Research Service [GM007185]
- JSPS
Purpose of review The lifelong stream of all blood cells originates from the pool of hematopoietic stem cells (HSCs) generated during embryogenesis. Given that the placenta has been recently unveiled as a major hematopoietic organ that supports HSC development, the purpose of this review is to present current advances in defining the origin and regulation of placental HSCs. Recent findings The mouse placenta has been shown to have the potential to generate multipotential myelo-lymphoid hematopoietic stem/progenitor cells de novo. The cellular origin of HSCs generated in the placenta and other sites has been tracked to the hemogenic endothelium by using novel genetic and imaging-based cell-tracing approaches. Transplantable, myelo-lymphoid hematopoietic stem/progenitor cells have also been recovered from the human placenta throughout gestation. Summary The discovery of the placenta as a major organ that generates HSCs and maintains them in an undifferentiated state provides a valuable model to further elucidate regulatory mechanisms governing HSC emergence and expansion during mouse and human development. Concurrent efforts to optimize protocols for placental banking and HSC harvesting may increase the therapeutic utility of the human placenta as a source of transplantable HSCs.
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