期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 23, 期 1, 页码 44-52出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.12.003
关键词
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资金
- NIH, CSHL WSBS NIH Kirschstein-NRSA pre-doctoral award [T32 GM065094]
- NIH
Piwi proteins, together with their bound Piwi-interacting RNAs, constitute an evolutionarily conserved, germline-specific innate immune system. The piRNA pathway is one of the key mechanisms for silencing transposable elements in the germline, thereby preserving genome integrity between generations. Recent work from several groups has significantly advanced our understanding of how piRNAs arise from discrete genomic loci, termed piRNA clusters, and how these Piwi-piRNA complexes enforce transposon silencing. Here, we discuss these recent findings, as well as highlight some aspects of piRNA biology that continue to escape our understanding.
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