期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 23, 期 1, 页码 53-62出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.12.005
关键词
-
资金
- Swiss National Science Foundation
- Swiss Cancer League
- Louis-Jeantet Foundation
- SFD-ALFEDIAM
- Werner Siemens Foundation
- Canton of Basel
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据