期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 22, 期 2, 页码 101-109出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.11.004
关键词
-
资金
- U.S. National Institutes of Health [R01 GM082918]
Polycomb group (PcG) proteins are concentrated in nuclear foci called PcG bodies. Although some of these foci are due to the tendency of PcG binding sites in the genome to occur in linear clusters, distant PcG sites can contact one another and in some cases congregate in the same PcG body when they are repressed. Experiments using transgenes containing PcG binding sites reveal that co-localization depends on the presence of insulator elements rather than of Polycomb Response Elements (PREs) and that it can occur also when the transgenes are in the active state. A model is proposed according to which insulator proteins mediate shuttling of PcG target genes between PcG bodies when repressed to transcription factories when transcriptionally active.
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