期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 21, 期 4, 页码 431-443出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.03.003
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资金
- Swiss National Science Foundation [PBZHP3-123324]
- Canadian Institutes for Health Research [MOP-14409, CTP-79838]
- Swiss National Science Foundation (SNF) [PBZHP3-123324] Funding Source: Swiss National Science Foundation (SNF)
In all animals, a key event in the transition from maternal control of development to control by products of the zygotic genome is the elimination of a significant fraction of the mRNAs loaded into the egg by the mother. Clearance of these maternal mRNAs is accomplished by two activities: the first is maternally encoded while the second requires zygotic transcription. Recent advances include identification of RNA-binding proteins that function as specificity factors to direct the maternal degradation machinery to its target mRNAs; small RNAs most notably microRNAs that function as components of the zygotically encoded activity; signaling pathways that trigger production and/or activation of the clearance mechanism in early embryos; and mechanisms for spatial control of transcript clearance.
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