期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 21, 期 4, 页码 511-517出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.04.003
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资金
- NCI NIH HHS [R21 CA143711, R21 CA143711-02] Funding Source: Medline
- NIGMS NIH HHS [R01 GM088365-02, R01 GM088365, R01 GM034028-27, R01 GM066826, R01 GM066826-04, R01 GM034028] Funding Source: Medline
MicroRNAs regulate temporal transitions in gene expression associated with cell fate progression and differentiation throughout animal development. Genetic analysis of developmental timing in the nematode Caenorhabditis elegans identified two evolutionarily conserved microRNAs, lin-4/mir-125 and let-7, that regulate cell fate progression and differentiation in C. elegans cell lineages. MicroRNAs perform analogous developmental timing functions in other animals, including mammals. By regulating cell fate choices and transitions between pluripotency and differentiation, microRNAs help to orchestrate developmental events throughout the developing animal, and to play tissue homeostasis roles important for disease, including cancer.
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