期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 21, 期 3, 页码 333-339出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.01.006
关键词
-
资金
- Muscular Dystrophy Association
- Hearst Fund
- National Institute of Neurological Disease and Stroke
- National Institute of Mental Health
- Nancy Lurie Marks Family Foundation
- Simons Foundation
- Manton Center for Orphan Disease Research
The unique size and complexity of the human cerebral cortex are achieved via a long and precisely regulated developmental process controlling neurogenesis, neuronal migration and differentiation. Traditionally, disorders of cortical development have been classified on the basis of the most obvious defects in one of these developmental steps. However, the more we learn about the cellular biological roles of genes that are essential for cortical development, the more we realize that these functions map onto molecular processes, but not so cleanly onto anatomical processes. Essential genes might be involved in both proliferation and migration as well as differentiation, reflecting roles for underlying molecular mechanisms in different phases of development and causing a stunning variety of cortical defects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据