期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 19, 期 1, 页码 60-66出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.12.001
关键词
-
资金
- Howard Hughes Medical Institute Funding Source: Medline
Intra-tumoral hypoxia (low oxygen [O-2] level) is an independent indicator of unfavorable patient diagnosis, and increasing evidence demonstrates that hypoxia contributes to a more aggressive tumor phenotype. Adaptation to hypoxia is predominantly regulated by two structurally related hypoxia inducible factors, HIF-1 alpha and HIF-2 alpha, which activate the expression of genes involved in proliferation, metabolism, angiogenesis, and metastasis. While highly homologous, HIF-1 alpha and HIF-2 alpha have been shown to have different roles in tumorigenesis dependent on specific tumor microenvironments. Here we summarize recent studies on HIF-2 alpha and discuss the potential mechanisms whereby it contributes to tumor aggressiveness.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据