期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 18, 期 2, 页码 130-136出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2007.12.008
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资金
- NIGMS NIH HHS [R01 GM030186-27, GM30186, R01 GM030186, R37 GM030186, R01 GM030186-25, R01 GM030186-26A1, R01 GM030186-25S1, R01 GM030186-24, R01 GM030186-22, R01 GM030186-23] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM030186, R01GM030186] Funding Source: NIH RePORTER
Transcription is the first step in gene expression, and its regulation underlies multicellular development and the response to environmental changes. Most studies of transcriptional regulation have focused on the recruitment of RNA polymerase to promoters. However, recent work has shown that, for many promoters, post-recruitment steps in transcriptional initiation are likely to be rate limiting. The rate at which RNA polymerase transitions from transcriptional initiation to elongation varies dramatically between promoters and between organisms and is the target of multiple regulatory proteins that can function to both repress and activate transcription.
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