期刊
CURRENT OPINION IN GASTROENTEROLOGY
卷 26, 期 6, 页码 547-553出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0b013e32833dccde
关键词
endoplasmic reticulum stress; homeostasis; inflammation; microbiome; necrotizing enterocolitis
资金
- NIH [DK044632, AI059346]
Purpose of review Recent evidence shows that disruption of Paneth cell homeostasis by induction of endoplasmic reticulum stress or autophagy, with consequent apoptosis, contributes to inflammation and morbidity in a variety of experimental mouse models. Recent findings Recent advances show that proinflammatory mediators in Paneth cell dense core secretory granules mediate tumor necrosis factor-alpha-induced shock, that Paneth cell alpha-defensins modulate the composition of the small intestinal microflora, that development of crypt organoid culture systems provides a novel means for investigating the crypt microenvironment, and that varied genetic defects that disrupt Paneth cell homeostasis are emergent as risk factors in inflammatory bowel disease. Summary This recent literature identifies Paneth cells as particularly sensitive targets of endoplasmic reticulum stress responses and implicates this unique small intestinal lineage in inflammatory bowel disease pathogenesis resulting from diverse heritable and environmental causes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据