期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 26, 页码 9701-9706出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0879-15.2015
关键词
age-related hearing loss; cholinergic inhibition; cochlea; inner hair cell; olivocochlear system; synaptic transmission
资金
- National Institute on Deafness and Other Communication Disorders [RO1 DC001508, T32 DC000023, P30 DC005211, F31 DC014184]
Hearing loss among the elderly correlates with diminished social, mental, and physical health. Age-related cochlear cell death does occur, but growing anatomical evidence suggests that synaptic rearrangements on sensory hair cells also contribute to auditory functional decline. Here we present voltage-clamp recordings from inner hair cells of the C57BL/6J mouse model of age-related hearing loss, which reveal that cholinergic synaptic inputs re-emerge during aging. These efferents are functionally inhibitory, using the same ionic mechanisms as do efferent contacts present transiently before the developmental onset of hearing. The strength of efferent inhibition of inner hair cells increases with hearing threshold elevation. These data indicate that the aged cochlea regains features of the developing cochlea and that efferent inhibition of the primary receptors of the auditory system re-emerges with hearing impairment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据