期刊
CURRENT OPINION IN CRITICAL CARE
卷 16, 期 6, 页码 533-539出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCC.0b013e32833e8412
关键词
acute kidney injury; biomarker; critical illness; cystatin C; glomerular filtration rate; renal replacement therapy; serum creatinine
资金
- Alberta Heritage Foundation for Medical Research
Purpose of review This review will summarize and discuss the role of cystatin C in the diagnosis of acute kidney injury. Recent findings Cystatin C is easily measured and has the characteristics of an ideal marker of kidney function. Data suggest that cystatin C is modified by age, sex, muscle mass, obesity, smoking status, thyroid function, inflammation, and malignancy. These factors suggest the need for age-specific and sex-specific reference standards. Cystatin C-based glomerular filtration rate estimates may perform better than creatinine in selected patient populations (elderly, children, transplantation, cirrhosis, malnourished). Cystatin C has been evaluated for the early diagnosis of acute kidney injury (AKI) in several populations. Serum cystatin C has value for the diagnosis of acute kidney injury; however, it has often performed similarly to creatinine. Urinary cystatin Chas potential as an early marker. Summary Cystatin C is an accurate biomarker for the early detection of AKI, and may, in selected populations, be superior to creatinine; however, data have been inconsistent. It also has reasonable discrimination for important outcomes such as death and renal replacement therapy (RRT). Additional studies are needed that focus on the cost-effectiveness of earlier detection of AKI with cystatin C compared with creatinine, and whether these biomarkers have complementary value.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据