期刊
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
卷 17, 期 6, 页码 360-368出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.cocis.2012.09.001
关键词
Carbon nanotubes; Liposome; Nano-carrier; Drug delivery; Photothermal therapy; Gene delivery; Toxicity
资金
- Chief Scientist Office of the Ministry of Health, Israel [300000-6083]
Carbon nanotubes (CNTs) possess outstanding properties and a unique physicochemical architecture, which may serve as an alternative platform for the delivery of various therapeutic molecules. This review focuses on recent progress in the field of CNTs for biomedical applications. After a short, general physico-chemical introduction to CNTs, we introduce different methods for CNT surface modification, facilitating their dispersions in physiological solutions, on the one hand, and binding a wide range of molecules or drug-loaded liposomes, on the other. We summarize imaging evidences on the structure of CNT-drug conjugates and their relevant uptake mechanisms by the cell. Lastly, we review current repots on CNT toxicity and new developments in CNT-based medical applications: photo-thermal therapy, drug delivery and gene therapy. (C) 2012 Elsevier Ltd. All rights reserved.
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