期刊
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
卷 14, 期 4, 页码 328-333出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e3283478727
关键词
cytokines; diet-induced obesity; high-fat diet; insulin resistance; intestinal inflammation
资金
- National Institutes of Health (NIH) [5-R01-DK040247-18, 5 R01 DK047769-11, 5-U01-CA105417-07]
- National Institute of Environmental Health Sciences [P30ES10126]
Purpose of review To highlight recent evidence supporting a concept that intestinal inflammation is a mediator or contributor to development of obesity and insulin resistance. Recent findings Current views suggest that obesity-associated systemic and adipose tissue inflammation promote insulin resistance, which underlies many obesity-linked health risks. Diet-induced changes in gut microbiota also contribute to obesity. Recent findings support a concept that high-fat diet and bacteria interact to promote early inflammatory changes in the small intestine that contribute to development of or susceptibility to obesity and insulin resistance. This review summarizes the evidence supporting a role of intestinal inflammation in diet-induced obesity and insulin resistance and discusses mechanisms. Summary The role of diet-induced intestinal inflammation as an early biomarker and mediator of obesity, and insulin resistance warrants further study.
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