期刊
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
卷 13, 期 2, 页码 145-149出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e3283357272
关键词
cardiomyopathy; ceramide; lipotoxicity; triglyceride
资金
- NHLBI NIH HHS [R01 HL045095, R01 HL073029, K99 HL112853, R00 HL112853] Funding Source: Medline
Purpose of review Diseases associated with ectopic disposition of lipids are becoming an increasingly important medical problem as the incidence of type 2 diabetes and obesity increases. One of the organs affected by lipotoxicity is the heart and this review presents an update on human and animal studies of this problem. Recent findings Human studies have clearly correlated heart dysfunction with the content of triglyceride. More recently human heart samples have been used to assess gene changes associated with altered lipid accumulation. Genetically altered mice have been created that develop lipotoxic cardiomyopathies and newer investigations are attempting to delineate curative therapies. Summary Human studies will confirm the metabolic changes associated with lipotoxic cardiomyopathy and, hopefully, animal studies will guide treatment options.
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