期刊
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
卷 13, 期 4, 页码 366-370出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e32833aab7f
关键词
chemokines; fibrosis; natural killer cells
资金
- Ministerium fur Wissenschaft und Forschung des Landes Nordrhein-Westfalen
- Bundesministerium fur Gesundheit
- Deutsche Forschungsgemeinschaft [SE 1922/2-1]
- European Union [BM0602]
- Commission of the European Communities [HEALTH-F2-2008-201100]
Purpose of review Obesity is associated with low-grade chronic inflammation in adipose tissue. This review presents an update on human and rodent studies analyzing the nature of fat-infiltrating immune cells, the time course of adipose tissue infiltration and underlying mechanisms. Recent findings Intensive studies in rodents have shown that not only cells of the innate immune system traffic into adipose tissue but also various lymphocytes of the adaptive immunity are involved in inflammatory processes in fat. Several studies also provide insight in the order of appearance of macrophages and lymphocytes during the onset of obesity. Adipocytes and preadipocytes are also active players by their secretion of chemotactic adipokines. Summary This review summarizes strong evidence for a link between the action of innate and adaptive immune systems in adipose tissue in the context of obesity and metabolism in rodents, but more studies in humans are necessary to relate this topic to human physiology. Targeting different immune cells at different stages of obesity may eventually lead to novel therapeutic approaches for the metabolic syndrome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据