期刊
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
卷 11, 期 4, 页码 385-392出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0b013e328304d970
关键词
beta cell function; enteroinsular axis; gene expression; insulin secretion; pancreatic islets; transcription factor 7 like-2
资金
- Swedish Research Council [31475113580]
- Heart and Lung Foundation
- Swedish Diabetes Research Society
- Diabetes Programme at Lund University
- Finnish Diabetes Research Society
- Sigrid Juselius Foundation
- Pahlsson Foundation
- Crafoord Foundation
- Folkhalsan Research Foundation
- Novo Nordisk Foundation
- European Union [EuroDia LSHM-CT-2006-518153]
- European Community
- EASD/EFSD/PFIZER Resource Award
Purpose of review The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2. Recent findings An important step to find genetic causes of type 2 diabetes in 2006 was the identification of the fact that variants in the gene encoding transcription factor 7 like-2 reproducibly increase susceptibility to type 2 diabetes in almost all populations studied. This gene has since then emerged as the most important type 2 diabetes gene. Genetic variants in transcription factor 7 like-2 confer a strong risk of type 2 diabetes possibly mediated by altering expression of transcription factor 7 like-2 in pancreatic islets. Risk variants in the transcription factor 7 like-2 influence insulin secretions both in vitro and in vivo. The risk T allele of this single nucleotide polymorphism also seems to have effects on the enteroinsular axis and the relationship between the incretin hormone glucose-dependent insulinotropic peptide and its target hormones, glucagon and insulin. Given transcription factor 7 like-2s' central role in the Writ signaling pathway, it would be important to define whether the variant is associated with increased or decreased Wnt signaling. Summary The fact that transcription factor 7 like-2 is by far the strongest type 2 diabetes susceptibility gene to date emphasizes the importance of exploring the potential of manipulating this pathway in future treatment of the disease.
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