期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 19, 期 -, 页码 67-75出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2014.01.006
关键词
-
资金
- National Science Foundation [CHE1058959]
- National Institute of Health [GM062211]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1058959] Funding Source: National Science Foundation
Metalloenzymes are among the major targets of protein design and engineering efforts aimed at attaining novel and efficient catalysis for biochemical transformation and biomedical applications, due to the diversity of functions imparted, by the metallo-cofactors along with the versatility of the protein environment. Naturally evolved protein scaffolds can often serve as robust foundations for sustaining artificial active sites constructed by rational design, directed evolution, or a combination of the two strategies. Accumulated knowledge of structure-function relationship and advancement of tools such as computational algorithms and unnatural amino acids incorporation all contribute to the design of better metalloenzymes with catalytic properties approaching the needs of practical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据