期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 23, 期 -, 页码 31-38出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2014.09.007
关键词
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资金
- Bill and Melinda Gates Foundation
- NIH [R01 AI049313]
- Dermatology Foundation
For decades immunologists thought that T cells solely recognize peptides bound to Major Histocompatibility Complex (MHC) proteins. Therefore, nearly all medical technology that seeks to measure and manipulate human T cells during immunization, infection, allergy and autoimmune diseases relies on peptide antigens. Newer insights into alpha beta and gamma delta T cell activation by CD1 or MR1 proteins greatly expand the biochemical range of T cell antigens to include lipids and non-peptidic small molecules. Moving beyond in vitro studies, the recent development of human CD1a, CD1b, CD1c and MR1 tetramers allows direct and specific enumeration of lipid-reactive and small molecule-reactive T cells, providing a new approach to study of T cell-mediated diseases.
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