期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 19, 期 -, 页码 126-134出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2014.02.001
关键词
-
资金
- Jacobs Institute of Molecular Medicine at Caltech
- NIH Ruth L. Kirschstein National Research Service Award [F32GM101792]
- NSF Graduate Research Fellowship
- Office of Naval Research [N00014-11-1-0205]
Advances in protein and metabolic engineering have led to wider use of enzymes to synthesize important molecules. However, many desirable transformations are not catalyzed by any known enzyme, driving interest in understanding how new enzymes can be created. The cytochrome P450 enzyme family, whose members participate in xenobiotic metabolism and natural products biosynthesis, catalyzes an impressive range of difficult chemical reactions that continues to grow as new enzymes are characterized. Recent work has revealed that P450-derived enzymes can also catalyze useful reactions previously accessible only to synthetic chemistry. The evolution and engineering of these enzymes provides an excellent case study for how to genetically encode new chemistry and expand biology's reaction space.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据