期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 17, 期 1, 页码 118-126出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.12.022
关键词
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资金
- NIH [R01 EB005011, R01 AI078947]
- Sungshin Women's University Research Grant [2012-2-21-003/1]
The past decade has seen rapid growth in the use of diverse compound libraries in classical phenotypic screens to identify modulators of a given process. The subsequent process of identifying the molecular targets of active hits, also called 'target deconvolution', is an essential step for understanding compound mechanism of action and for using the identified hits as tools for further dissection of a given biological process. Recent advances in 'omics' technologies, coupled with in silico approaches and the reduced cost of whole genome sequencing, have greatly improved the workflow of target deconvolution and have contributed to a renaissance of 'modern' phenotypic profiling. In this review, we will outline how both new and old techniques are being used in the difficult process of target identification and validation as well as discuss some of the ongoing challenges remaining for phenotypic screening.
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