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Metabolic and cellular organization in evolutionarily diverse microalgae as related to biofuels production

期刊

CURRENT OPINION IN CHEMICAL BIOLOGY
卷 17, 期 3, 页码 506-514

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ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.02.027

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资金

  1. Air Force Office of Scientific Research (AFOSR) [FA9550-08-1-0178]
  2. US Department of Energy [DE-EE0001222, DE-EE0003373, DE-EE0003046]
  3. National Science Foundation [CBET-0903712]
  4. California Energy Commission's 'California Initiative for Large Molecule Sustainable Fuels' [500-10-039]
  5. UCMexus grant [CN-10-454]
  6. Department of Energy Office of Science Graduate Fellowship Program (DOE SCGF)
  7. ORISE-ORAU [DE-AC05-06OR23100]
  8. National Institutes of Health Marine Biotechnology Training Grant Fellowship
  9. Department of Defense through the National Defense Science & Engineering Graduate Fellowship Program
  10. AFOSR [FA9550-08-1-0170, FA9550-08-1-0403]
  11. Directorate For Engineering
  12. Div Of Chem, Bioeng, Env, & Transp Sys [0903712] Funding Source: National Science Foundation

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Microalgae are among the most diverse organisms on the planet, and as a result of symbioses and evolutionary selection, the configuration of core metabolic networks is highly varied across distinct algal classes. The differences in photosynthesis, carbon fixation and processing, carbon storage, and the compartmentation of cellular and metabolic processes are substantial and likely to transcend into the efficiency of various steps involved in biofuel molecule production. By highlighting these differences, we hope to provide a framework for comparative analyses to determine the efficiency of the different arrangements or processes. This sets the stage for optimization on the based on information derived from evolutionary selection to diverse algal classes and to synthetic systems.

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