期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 15, 期 5, 页码 657-663出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2011.07.023
关键词
-
资金
- NIH [1R01GM086451]
- NSF [MCB0845156]
- AHA
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1062243] Funding Source: National Science Foundation
Ribosome assembly involves rRNA transcription, modification, folding and cleavage from precursor transcripts, and association of ribosomal proteins (Rps). In bacteria, this complex process requires only a handful of proteins in addition to those needed for rRNA transcription, modification and cleavage, while in eukaryotes a large machinery comprising similar to 200 proteins in the yeast S. cerevisiae has been identified. Furthermore, while the bacterial assembly factors generally produce only cold-sensitive phenotypes upon deletion, most of the eukaryotic assembly factors are essential, comprising similar to 20% of essential yeast proteins. This review explores recent rapid progress in the structural and functional dissection of the 40S assembly machinery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据