期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 15, 期 3, 页码 452-457出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2011.03.014
关键词
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资金
- US Department of Energy [DE-FG02-04ER46156]
- National Institutes of Health [P01 GM55876, R01 HL085303]
- University of Pennsylvania's Nano/Bio Interface Center through the National Science Foundation (NSF) NSEC [DMR-0425780]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1120901] Funding Source: National Science Foundation
Computational and theoretical methods are advancing protein design as a means to create and investigate proteins. Such efforts further our capacity to control, design and understand biomolecular structure, sequence and function. Herein, the focus is on some recent applications that involve using theoretical and computational methods to guide the design of protein sequence ensembles, new enzymes, proteins with novel cofactors, and membrane proteins.
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