期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 13, 期 5-6, 页码 633-640出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.08.017
关键词
-
资金
- National Institutes of Health [HL62244, HL096972, GM38060, GM090127, RR023764, HL094463]
Heparin, the focus of this review, is a crucially important anticoagulant drug produced from animal sources, which was contaminated last year leading to a number of adverse side effects, some resulting in death. Heparin is a highly acidic polysaccharide and a member of a family of biopolymers called glycosaminoglycans. The structure and activities of heparin are detailed along with recent advances in heparin structural analysis and biological evaluation. Current state-of-the-art chemical and chemoenzymatic synthesis of heparin and new approaches for its metabolic engineering are described. New technologies, including microarrays and digital microfluidics, are proposed for high-throughput synthesis and screening of heparin and for the fabrication of an artificial Golgi.
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