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Diversification of echinomycin molecular structure byway of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway

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CURRENT OPINION IN CHEMICAL BIOLOGY
卷 13, 期 2, 页码 189-196

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ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.02.012

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Echinomycin, a bis-intercalator antitumor cyclic peptide, is biosynthesized by a unique nonribosomal peptide synthetase (NRPS). Successful heterologous expression of the whole gene cluster of echinomycin in Escherichia coli let us to investigate a further application of echinomycin NRPS. To construct a cyclic peptide library, our approach through both chemoenzymatic and rational genetic engineering has been successfully demonstrated. These achievements provided the further support that E coli-based system can serve as a flexible yet robust platform for producing complex natural products and their analogs.

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