期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 12, 期 4, 页码 448-456出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2008.06.028
关键词
-
资金
- Archemix Corp.
Aptamers, a promising new class of therapeutics, are single-stranded oligonucleotides generated via an in vitro selection process that bind to and inhibit the activity of target proteins in a manner similar to therapeutic antibodies. In order to enhance the drug-like character of aptamers, oligonucleotide libraries containing modified nucleotides are increasingly being used for selection. Principally, the choice of modifications aims to increase aptamer potency by enhancing nuclease-resistance, or increasing target affinity by providing more target recognition functionality or generating more stable aptamer structures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据