期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 12, 期 5, 页码 539-555出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2008.05.010
关键词
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资金
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Biotechnology and Biochemical Sciences Research Council
- Royal Society-Wolfson Research Merit Award
The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.
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