期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 12, 期 1, 页码 18-24出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2008.01.021
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资金
- NCI NIH HHS [R21 CA112145-02, R21 CA112145] Funding Source: Medline
- NHLBI NIH HHS [R01 HL062198] Funding Source: Medline
- NIGMS NIH HHS [GM 075304, F32 GM074537, R01 GM50389, R01 GM050389, R01 GM050389-14, R01 GM075304, R01 GM075304-03] Funding Source: Medline
Accumulating evidence reveals hydrogen peroxide as a key player both as a damaging agent and, from emerging evidence over the past decade, as a second messenger in intracellular signaling. This rather mild oxidant acts upon downstream targets within signaling cascades to modulate the activity of a host of enzymes (e.g. phosphatases and kinases) and transcriptional regulators through chemoselective oxidation of cysteine residues. With the recent development of specific detection reagents for hydrogen peroxide and new chemical tools to detect the generation of the initial oxidation product, sulfenic acid, on reactive cysteines within target proteins, the scene is set to gain a better understanding of the mechanisms through which hydrogen peroxide acts as a second messenger in cell signaling.
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