期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 12, 期 5, 页码 556-564出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2008.07.013
关键词
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资金
- National Institutes of Health [CA84374, U19 CA113297]
- NATIONAL CANCER INSTITUTE [U19CA113297, R01CA084374] Funding Source: NIH RePORTER
Glycodiversification of natural products is an effective strategy for small molecule drug development. Recently, improved methods for chemo-enzymatic synthesis of glycosyl donors has spurred the characterization of natural product glycosyltransferases (GTs), revealing that the substrate specificity of many naturally occurring GTs as too stringent for use in glycodiversification. Protein engineering of natural product GTs has emerged as an attractive approach to overcome this limitation. This review highlights recent progress in the engineering/evolution of enzymes relevant to natural product glycodiversification with a particular focus upon GTs.
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