期刊
CURRENT OPINION IN CELL BIOLOGY
卷 31, 期 -, 页码 46-55出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.08.003
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- Deutsche Forschungsgemeinschaft
Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/beta-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting as both Wnt activators and Wnt inhibitors. Recent discoveries suggest that CK1 members act in a coordinated manner to regulate early responses to Wnt and notably that their enzymatic activity is regulated. Here, I provide a brief update of CK1 function and regulation in Wnt/beta-catenin signaling.
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