期刊
CURRENT OPINION IN CELL BIOLOGY
卷 29, 期 -, 页码 39-45出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.03.008
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资金
- NIH [RO1GM099844, R01GM097194]
- G. Harold and Leila Y. Mathers Foundation
- Boehringer Ingelheim Fellowship
- NSF Graduate Research Fellowship
- Gladstone Institutes
Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane. Additionally, large LDs can form either by growth of existing LDs or by the combination of smaller LDs through several distinct mechanisms. Here, we review recent insights into the molecular process governing LD biogenesis and highlight areas of incomplete knowledge.
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