期刊
CURRENT OPINION IN CELL BIOLOGY
卷 25, 期 4, 页码 495-505出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2013.04.008
关键词
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类别
资金
- National Institutes of Health [R01 AR048155, R01 EY015625, R21 HL096865, R21 AI092398]
- Netherlands Organisation for Scientific Research [ALW 813.08.001]
- Institut Curie
- CNRS
- INSERM
- Foundation ARC pour la recherche sur le cancer [SL220100601359]
Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs.
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