期刊
CURRENT OPINION IN CELL BIOLOGY
卷 24, 期 6, 页码 765-774出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2012.08.014
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资金
- 'Thousand Young Talents' program of China
- National Natural Science Foundation of China
- National Laboratory of Biomacromolecules
- Strategic Priority Research Program of the Chinese Academy of Sciences
- MINECO
- Cellex Foundation
- G. Harold and Leila Y. Mathers Charitable Foundation
- Leona M. and Harry B. Helmsley Charitable Trust
- Ellison Medical Foundation
A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.
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