期刊
CURRENT OPINION IN CELL BIOLOGY
卷 24, 期 1, 页码 116-124出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2011.11.001
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资金
- Nevus Outreach
- Swiss Foundation for Research on Myopathies
- Swiss National Science Foundation [31003A-130742]
- Swiss National Science Foundation (SNF) [31003A_130742] Funding Source: Swiss National Science Foundation (SNF)
Integrin-dependent cell adhesions come in different shapes and serve in different cell types for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular matrix to the formation and stabilization of immunological and chemical synapses. A major challenge consists in the identification of adhesion-specific as well as common regulatory mechanisms, motivating the need for a deeper analysis of protein-protein interactions in the context of intact focal adhesions. Specifically, it is critical to understand how small differences in binding of integrins to extracellular ligands and/or cytoplasmic adapter proteins affect the assembly and function of an entire focal adhesion. By using the talin-integrin pair as a starting point, I would like to discuss how specific protein-protein and protein-lipid interactions can control the behavior and function of focal adhesions. By responding to chemical and mechanical cues several allosterically regulated proteins create a dynamic multifunctional protein network that provides both adhesion to the extracellular matrix as well as intracellular signaling in response to mechanical changes in the cellular environment.
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