期刊
CURRENT OPINION IN CELL BIOLOGY
卷 23, 期 1, 页码 4-13出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2010.10.007
关键词
-
类别
资金
- NIH/NIGMS [GM059609]
- University of California Cancer Research Coordinating Committee
- American Heart Association [0715035Y]
In cells the de novo nucleation of actin filaments from monomers requires actin-nucleating proteins. These fall into three main families - the Arp2/3 complex and its nucleation promoting factors (NPFs), formins, and tandem-monomer-binding nucleators. In this review, we highlight recent advances in understanding the molecular mechanism of actin nucleation by both well-characterized and newly identified nucleators, and explore current insights into their cellular functions in membrane trafficking, cell migration and division. The mechanisms and functions of actin nucleators are proving to be more complex than previously considered, with extensive cooperation and overlap in their cellular roles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据