期刊
CURRENT OPINION IN CELL BIOLOGY
卷 23, 期 4, 页码 435-442出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2011.04.007
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资金
- Italian Ministry of Health
- Association Francaise contre les Myopathies
- Fondazione Telethon
- National Institutes of Health [GM071832]
- G. Harold and Leila Y. Mathers Foundation
The endoplasmic reticulum is a multifunctional organelle composed of functionally and morphologically distinct domains. These include the relatively planar nuclear envelope and the peripheral ER, a network of sheet-like cisternae interconnected with tubules that spread throughout the cytoplasm. The ER is highly dynamic and the shape of its domains as well as their relative content are in constant flux. The multiple forces driving these morphological changes depend on the interaction between the ER aid microtubules, membrane fusion and fission events and the action of proteins capable of actively shaping membranes. The interplay between these forces is ultimately responsible for the dynamic morphology of the ER, which in turn is crucial for properly executing the varied functions of this organelle.
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